ESR1 and neurodegenerative disease: The target analysis revealed canonical pathways linked to nervous system physiology, neurodegenerative diseases, mitochondrial dysfunction, oxidative phosphorylation, immunological function and inflammatory responses (e.g, IL-6 and IL-10), VEGF signaling, cardiac hypertrophy and cardiac beta-adrenergic signaling, as well as insulin secretion, estrogen receptor, and glucocorticoid receptor signaling canonical pathways (Supplementary Figures S1–S4).