In the rat mesangial cells induced by high glucose and tumor necrosis factor-α (TNF-α), the total flavonoids of lychee seed distinctly decreased the protein expression of TGF-β1, FN, and Col IV, which indicated the total flavone might improve the diabetic nephropathy fibrosis process (Liu, 2016; Liu et al., 2016). The gene discussed is TNF; the disease is diabetic kidney disease.