In patients with aortic stenosis, and mice subjected to transverse aortic constriction, pressure overload resulted in decreased levels of BMP7 and pSmad1/5/8 (the intracellular effectors of BMP7) and an increase in TGF-β and pSmad2/3 (Merino et al., 2016). Here, BMP7 is linked to aortic stenosis.