HOTTIP could maintain the stemness of cancer stem cells (PCSCs) through the HOTTIP/WDR5/HOXA9/Wnt axis in pancreatic cancer (Fu et al., 2017); lncRNA H19 mediated the methotrexate resistance in colorectal cancer through activating Wnt/β-catenin signaling (Wu et al., 2017). The gene discussed is HOTTIP; the disease is cancer.