As a widely studied lncRNA, Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been reported to be frequently up-regulated in tumors, and closely correlate with tumor grades and metastasis in multiple cancers, such as lung cancer, breast cancer, prostate cancer, osteosarcoma, gastric cancer (Schmidt et al., 2011; Chang et al., 2020; Goyal et al., 2021). The gene discussed is MALAT1; the disease is osteosarcoma.