In recent years, with the advancement of genetic testing technology, Alpers syndrome caused by NON-POLG genes has also been continuously reported, including mitochondrial aminoacyl transfer RNA synthetase related genes (PARS2, CARS2, FARS2 and NARS2) and γ-GABA receptor related genes Gene (GABRB2). This evidence concerns the gene NARS2 and Alpers syndrome.