POLG and microcephaly: As demonstrated in Table 2, Age at onset, Age at seizure onset, Time of death showed a significant relationship with the POLG or NON-POLG group,p < 0.05; As demonstrated in Table 2, Age at onset, Age at seizure onset, Time of death showed a significant relationship with the POLG or NON-POLG group,p < 0.05; microcephaly, Infantile spasm, Hepaticdys function, EEG feature showed a significant relationship in POLG or NON-POLG group, p < 0.05 (Table 3); As can be seen from the above table, there was a significant difference in survival rate between the NON-POLG group and the POLG group (p < 0.05).