In recent years, large population-based studies report that low ADAMTS13 activity was correlated with a risk of ischemic stroke (Sonneveld et al., 2015) and dementia (Wolters et al., 2018) independent of other known demographic and cerebrovascular risk factors, but studies on the relationship between ADAMTS13 activity and CSVD are little. The gene discussed is ADAMTS13; the disease is dementia.