BCAR1 and breast cancer: In non-neuronal cells such as osteoclasts, Pyk2 is implicated in the regulation of actin-cytoskeleton downstream of integrins through its interaction with proteins like the Crk-associated substrate p130Cas (also known as breast cancer anti-estrogen resistance protein 1, BCAR1) and paxillin, in a manner similar to FAK [review in Kong et al. (2020)].