This inhibitor improves several histological and behavioral parameters in APPSwe/PSEN1ΔE9 mice [bearing 2 human mutations responsible for familial AD, APP KM670/671NL (Swedish) and presenilin-1 (PSEN1) ΔE9 (Jankowsky et al., 2004)]; Kaufman et al. (2015). This evidence concerns the gene APP and Alzheimer disease.