APP and Alzheimer disease: It was first proposed that the scaffolding protein Ran-binding protein 9 (RanBP9), which is markedly increased in AD brains, promotes Aβ1–42 generation by scaffolding APP/BACE1/LRP complexes together and accelerating APP endocytosis through a mechanism that involves disruption of Pyk2/paxillin signaling (Woo et al., 2012).