Mutations in Parkin gene associated with autosomal recessive juvenile onset of PD (Kitada et al., 1998) or lack of the Parkin gene facilitate ASIC1a currents in hippocampal neurons evoked by application of acidic extracellular solution, and increase vulnerability of dopaminergic neurons, suggesting a significant role of ASIC1a in PD pathophysiology (Joch et al., 2007). Here, PRKN is linked to Parkinson disease.