Glioma cells express both ionotropic and metabotropic glutamate receptors (de Groot and Sontheimer, 2011) and the increased extracellular glutamate levels in proximity of the tumor mass (Behrens et al., 2000) promote survival, growth and migration in part through the activation of AMPA receptors and, consequently, Rho-Akt pathway (Ishiuchi et al., 2007). Here, AKT1 is linked to neoplasm.