Within the tumor core, a subpopulation of CD206+CD169+CD209+ macrophages was found specifically associated with blood vessels (Friebel et al., 2020) and TAMs expressing hypoxic and pro-angiogenic genes HIF1A and VEGF-A have been described in human gliomas and might be enriched in hypoxic regions (Darmanis et al., 2017; Sankowski et al., 2019). Here, VEGFA is linked to neoplasm.