CDKN2A and oligodendroglioma: For example, cells with aberrant EGFR and Ink4A/Arf deletion acquire expression of astrocytes markers (Bachoo et al., 2002), while PDGFB overexpression is sufficient to de-differentiate astrocyte cultures and to form oligodendroglioma or oligoastrocytoma in vivo (Dai et al., 2001).