PPARGC1A and obesity due to melanocortin 4 receptor deficiency: The diet induced obesity significantly alters the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), a master regulator of mitochondrial biogenesis, also affecting the expression of its transcriptional complexes in hippocampus (Rius-Perez et al., 2020).