The cumulative line of evidence suggests that Aβ peptide for amyloid plaques and tau for neurofibrillary tangles work synergistically to alter neuronal function in AD, further demonstrating that Aβ triggers Tau pathology (Gotz et al., 2001; Lewis et al., 2001; Hurtado et al., 2010). Here, MAPT is linked to amyloidosis.