HMGCR and obesity due to melanocortin 4 receptor deficiency: Additionally, it has also been demonstrated that miR-144 downregulates hydroxymethylglutaryl-CoA reductase (hmgcr), cholesterol 7a-monooxygenase A1 (cyp7a1), and ABCA1 in a model of diet induced obesity (Chen et al., 2020).