Interestingly, there is no effect of Nlgn1, Nlgn4X, Nlgn4Y or Nlgn2 on glioma proliferation, and no significant association between Nlgn2 expression and patient survival in adult glioblastoma multiforme (GBM), suggesting a unique function of Nlgn3 in brain tumors. This evidence concerns the gene NLGN3 and central nervous system cancer.