Indeed, gene mutations in various proteins that regulate endocytosis have been identified in neurodevelopmental disorders, predominantly epilepsy and intellectual disability (Bonnycastle et al., 2020; John et al., 2021), including proteins such as VAMP4 which has specific roles in activity-dependent bulk endocytosis (Monies et al., 2017). The gene discussed is VAMP4; the disease is Intellectual disability.