NPY and focal epilepsy: Moreover, gene therapy trials with symptomatic vector construct approaches are also on the way targeting hyperexcitability in more frequent focal epilepsies with intracerebral injections of viral vectors mediating focal overexpression of engineered Kv1.1 potassium channel (NCT04601974; lentivirus; Snowball et al., 2019) or neuropeptide Y and its antiepileptic receptor Y2 (AAV1-NPY-IRES-Y2; CG01; Szczygiel et al., 2020; Cattaneo et al., 2021).