MAPT and Alzheimer disease: AD usually has a slow progression (No authors listed, 2020), and although what defines AD as a unique neurodegenerative disease (among others conditions that could lead to dementia) are the β-amyloid plaques and the neurofibrillary tau deposits (Jack et al., 2018), there is still a lot of work to be done to delineate the AD pathogenesis causal pathways.