IGF-1, a protein produced by the liver, has been suggested to increase osteoblast recruitment, bone matrix formation, and collagen synthesis.11, 12, 13 Insulin deficiency and hyperglycaemia, changes in advanced glycation end products (AGEs) axis, decreased IGF-1, and changes in osteocalcin are some factors that lead to decreased bone quality in diabetic patients.14 This evidence concerns the gene IGF1 and Hyperglycemia.