The blood routine examination of c.−248A>G carrier was normal, mainly manifested as a decrease in HbA2 content [33].The phenotype of c.316-45G>C, c.316-179A>C, and c.315+308delA combined with other types of α-thalassemia may be as silent or mild α-thalassemia. The gene discussed is HBA2; the disease is thalassemia.