In this work we only consider the effects of tau and TDP-43 pathology on MTL structure since recent work studying the contribution of mixed pathology to MTL atrophy in AD showed no clear relationship between neurodegeneration and either Aβ or \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α-synuclein [6]. Here, TARDBP is linked to Alzheimer disease.