NRIP1 and neoplasm: Intriguingly, our study demonstrated that miR-195-5p played protective action by repressing proliferation and invasion capabilities, facilitating apoptosis of PTC cells and restraining the growth of tumor xenografts, while the functions were all abrogated following CircRNA NRIP1 overexpression in PTC cells and xenografts tissues, which further confirmed that CircRNA NRIP1 could sponge miR-195-5p to accelerate the PTC tumor development.