Currently, biomarkers are utilized for clinical diagnosis of patients with PC, which include blood-based prostate-specific antigen (PSA) [4], Prostate Health Index (PHI) [5], 4 K score (total PSA, free PSA, intact PSA, and human kallikrein-related peptidase 2) [6]; urine-based- PCA3(prostate cancer gene 3) [7], SelectMDx(detection of HOXC6 and DLX1 mRNA levels) [8], ExoDx Prostate IntelliScore (liquid biopsy test indicated for men 50 years of age and older with a PSA 2–10 ng/mL, or PSA in the “gray zone”, considering an initial biopsy) [9, 10]. The gene discussed is PROS1; the disease is pachyonychia congenita.