Importantly, the changes in pregnancy in endothelial cell Gch1 deficient mice were entirely dependent upon maternal endothelial cell Gch1, not fetal Gch1, because WT mice mated with Gch1fl/flTie2cre male mice, resulting in litters of the same 1:1 ratio of WT and Gch1fl/flTie2cre offspring, showed no hypertension or fetal growth restriction. The gene discussed is GCH1; the disease is hypertensive disorder.