A study from our laboratory has shown that SMAR1 represses the transcription of signal transducer and activator of transcription 3 (STAT3) in T cells by binding to the matrix attachment region, −229 to −478 and −660 to −840 upstream of transcription start site (TSS) sequences present on its promoter, whereas upon interleukin (IL)‐6‐mediated suppression of SMAR1 or in the SMAR1 knockdown condition, there is an enhanced expression of STAT3, which leads to the development of ulcerative colitis and hence intensifies the risk of establishment of colorectal cancer [36]. This evidence concerns the gene STAT3 and colorectal cancer.