In vivo study, dietary fiber protected against DKD through modulation of the gut microbiota, enriched SCFAs‐producing bacteria, and increased SCFA production, so that it reduced expression of genes encoding inflammatory cytokines, chemokines, and fibrosis‐promoting proteins in diabetic kidneys via GPR43 and GPR109A.33 The gene discussed is HCAR2; the disease is diabetic kidney disease.