Although the expression of TAC1, PTGS2 and FGF1 were related with many kinds of tumorigenesis, such as non-small cell lung cancer, pancreatic ductal cancer, colorectal cancer, squamous cell carcinoma, gastric cancer and clear cell renal cell carcinoma[26–33], but these genes expression did not exhibit significant change as expected as the microarray results, indicating that these three genes may not the pivotal gene that participate in the metastasis of NB. The gene discussed is FGF1; the disease is neuroblastoma.