HSPB8 is a component of the chaperone-assisted selective autophagy machinery that promotes the removal of ALS-related variants of SOD1 and TDP-43 as well as aggregation-prone dipeptides derived from mutant C9orf72 (Crippa et al. 2016; Cristofani et al. 2017, 2018). Here, C9orf72 is linked to amyotrophic lateral sclerosis.