Elevated levels of IL-6 and CRP, indicating inflammatory activity, were not only associated with AF severity, but were also identified as prognostic markers for AF recurrence after CV and catheter ablation, as well as for stroke.[2, 27] Elevated CRP and IL-6 levels have previously been associated with increased LA size and long-lasting AF episodes indicating an association to LA structural changes and remodeling [28]. This evidence concerns the gene IL6 and stroke disorder.