To study the role of the Hippo pathway in the MD tissue of patient with FICRD, the YAP1 (a downstream mediator of the Hippo pathway) signature was specifically enriched in the MD tissue after a gene set enrichment analysis (GSEA) (Supplementary Table 1), suggesting that YAP1 may play a role in FICRD. The gene discussed is YAP1; the disease is Menkes disease.