Altogether, these studies indicate that Gα12/13 proteins drive several steps of the cancer cell invasion and metastasis cascade through classical Rho-mediated signaling pathways and via crosstalk with several other pro-metastatic signaling pathways such as Wnt/β-catenin, Hippo-YAP, tyrosine kinases, and sex hormones. The gene discussed is RHO; the disease is cancer.