Further, Stromal Derived Factor 1-induced CXCR4-Gα13-Rho signaling axis was shown to be important not only for cancer cell invasion and local migration but also for transendothelial migration, an important step for breast cancer cell intravasation into blood vessels and extravasation into a distant site of metastasis [74]. This evidence concerns the gene CXCR4 and breast cancer.