CDH1 and cancer: In addition to these, our own studies demonstrated that Gα12/13 interact directly with the cytoplasmic domain of E-cadherin (E-cad) and cause the release of the transcriptional activator β-catenin, leading to loss of cell–cell adhesion, which is an initial step of the epithelial to mesenchymal transition (EMT) and cancer cell migration [88, 89].