Recent investigations using a synthetic biology approach in which artificial ligands were used to stimulate GPCR-Gα12/13 signaling found that Gα12/13-induced proliferation of ovarian cancer cells is mediated via the activation of the transcriptional coactivator YAP1, a key component of the Hippo signaling pathway [52]. The gene discussed is YAP1; the disease is ovarian carcinoma.