The tumor volume of the si-TMEM161B-AS1 transfection group and hsa-miR-27a-3p angomir transfection group were significantly smaller than that of the NC group, and the si-TMEM161B-AS1 + hsa-miR-27a-3p angomir transfection group had the smallest tumor volume (Fig. S2c, d). The gene discussed is TMEM161B; the disease is neoplasm.