ZIC1 and central nervous system cancer: We found that 11 genes were both up-regulated in glioma cells and TMZ-insensitive U251 cells, namely ZIC1, TMEM154, PRRX1, ITGA4, APOBEC3F, ADAM12, ANTXR2, PHLDA1, CALCRL, GALNT5 and CD44 (Fig. 1c).