Collectively, these findings manifest that compartment switching induced by Arid1a depletion modulates the transcription of some cancer-related genes, such as Pmp22 [39, 40], Atg10 [41], Gsc [42, 43], Rnf125 [44], and Cdh5 [45], which have been known to be involved in tumorigenesis. The gene discussed is GSC; the disease is cancer.