Except for PMP22 and GSC mentioned above, the downregulation of ATG10, with A to B transition, may facilitate metastasis of colorectal cancer cells [41]; transcription factor SIX2, with B to A switch, has been reported as a critical regulator for the stemness of breast cancer cells that enables metastatic colonization [59, 60]. The gene discussed is SIX2; the disease is colorectal cancer.