Moreover, ACTL6A maintains the stem-like phenotype in keratinocytes [13], stimulates neural progenitor cell proliferation [34, 35], enhances the osteosarcoma and hepatocellular carcinoma cell cancer phenotype [16, 17], and drives an aggressive epidermal squamous cell carcinoma phenotype [22]. The gene discussed is ACTL6A; the disease is osteosarcoma.