To our knowledge ACTL6A function has not been studied in mesothelioma; however, it is important to examine the role of ACTL6A in mesothelioma, since it regulates key pathways, including YAP1/TAZ/TEAD and p21Cip1 signaling, that have been implicated as important in mesothelioma cancer progression [24–27]. The gene discussed is CDKN1A; the disease is mesothelioma.