CASP3 and subarachnoid hemorrhage: This speculation was supported by the data from previous studies, which suggested that treatment with zVAD.fmk at 2 and 5.6 mg/kg via intraperitoneal injection decreased caspase-3 activity, resulting in reduced brain edema and improved neurological function in rats with focal cerebral I/R injury and rats with subarachnoid hemorrhage [25, 26].