Hallmarks of necroptosis including the phosphorylation of RIPK1 and elevated levels of insoluble RIPK1, RIPK3 and MLKL are found in post-mortem human pathological samples such as patients with amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) [6–8]. Here, RIPK3 is linked to amyotrophic lateral sclerosis.