Compared to the control mice, we found that there was no significant alteration in the expression level of IDE in the loganin-treated 3xTg-AD mice, but the expression levels of APP, ADAM10 and BACE1 were remarkable change in the 3xTg-AD mice treated with loganin (Figure 2B, 2C). This evidence concerns the gene BACE1 and Alzheimer disease.