CSF3 and Decreased total neutrophil count: Consistently with the time to the onset of G3-4 neutropenia and FN, the first administration of G-CSF mainly occurred in the first 2 months (N = 145, 63.9%), whereas it was progressively less common during the subsequent months [during the third or fourth month: N = 66 (29.1%); after the fourth month: N = 16 (7%)] (Figure 1).