COL1A1 and steatosis: Additionally, 47 transcripts increased in this NASH gene signature (29) were reduced in HFD+AC261066/HFD; these include common markers of steatosis, such as Srebf1, Pparg, and Cidea, and transcripts involved in fibrogenesis, such as Col1a1, Col1a2, and Mmp12 (14, 15, 29).