Additionally, 47 transcripts increased in this NASH gene signature (29) were reduced in HFD+AC261066/HFD; these include common markers of steatosis, such as Srebf1, Pparg, and Cidea, and transcripts involved in fibrogenesis, such as Col1a1, Col1a2, and Mmp12 (14, 15, 29). This evidence concerns the gene MMP12 and metabolic dysfunction-associated steatohepatitis.