Using multiomics data, Krishnan et al. (20) reported key driver genes underlying NAFLD progression: Pklr (Pyruvate Kinase L/R), Fasn, Thrsp, and Chchd6. We also observed significantly greater hepatic mRNA levels of these four genes in the HFD group compared with the chow group (Fig. 2). Here, PKLR is linked to metabolic dysfunction-associated steatotic liver disease.