Additionally, 47 transcripts increased in this NASH gene signature (29) were reduced in HFD+AC261066/HFD; these include common markers of steatosis, such as Srebf1, Pparg, and Cidea, and transcripts involved in fibrogenesis, such as Col1a1, Col1a2, and Mmp12 (14, 15, 29). The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatohepatitis.