FASN and metabolic dysfunction-associated steatotic liver disease: Using multiomics data, Krishnan et al. (20) reported key driver genes underlying NAFLD progression: Pklr (Pyruvate Kinase L/R), Fasn, Thrsp, and Chchd6. We also observed significantly greater hepatic mRNA levels of these four genes in the HFD group compared with the chow group (Fig. 2).