RUNX2 and type 2 diabetes mellitus: The mechanical stimulation of downhill running can also activate miR-495 expression in the bones of T2DM mice [41], and miR-495 activates downstream dishevelled 2 (DVL-2), while the expression of upregulated DVL will activate Wnt3a and downstream phosphorylation of β-catenin and Runx2 expression [9].