Then the logistic regression model 2 was reconstructed with these 21 genes as the variables, and 10 significant genes involved in atherosclerosis including STAT3, IL1RN, C5AR1, CXCL16, IL17RA, SLC11A1, TLR2, IL1B, LYN and CKAP4 were selected. The gene discussed is STAT3; the disease is atherosclerosis.