Our results suggest that the high-level C5aR expression in tumor tissue predicted unsatisfactory overall survival (OS) (HR = 1.92, 95% CI:1.47–2.50, P < 0.001) and recurrence-free survival (RFS) (HR = 2.19, 95% CI:1.47–3.27, P < 0.001). Here, C5AR1 is linked to neoplasm.