These factors in turn may activate the PI3K/AKT pathway via receptor tyrosine kinases (RTKs), leading to subsequent activation of mammalian target of rapamycin complex 1 (mTORC1) mTORC2, which then further promote HIF expression to contribute to ccRCC [9, 34]. The gene discussed is AKT1; the disease is nonpapillary renal cell carcinoma.