Using the co-expression tool on expression data extracted from renal cancer cell samples of CCLE, we obtained lists of genes that were co-expressed with FN1, C3, and C3AR1 and harbored a correlation coefficient > 0.5 or < − 0.5 and P-value < 0.01 (Supplementary Table S10). This evidence concerns the gene C3AR1 and renal carcinoma.