The survival analysis for the hub genes showed that the alteration in the expression of FN1, FCER1G, TIMP1, ADCY7, TNFRSF1B, CALU, LGALS1, and CASR was involved in worsening of OS, thereby indicating vital roles of these genes in ccRCC carcinogenesis, progression, or invasion. The gene discussed is TNFRSF1B; the disease is nonpapillary renal cell carcinoma.