Next, the correlation between the OS of the cancer patients and hub genes was analyzed and the results showed that ccRCC patients with altered expression of FN1, FCER1G, TIMP1, ADCY7, TNFRSF1B, CALU, LGALS1, and CASR showed worse overall survival (Supplementary Fig. S2A). This evidence concerns the gene TNFRSF1B and nonpapillary renal cell carcinoma.