The survival analysis for the hub genes showed that the alteration in the expression of FN1, FCER1G, TIMP1, ADCY7, TNFRSF1B, CALU, LGALS1, and CASR was involved in worsening of OS, thereby indicating vital roles of these genes in ccRCC carcinogenesis, progression, or invasion. This evidence concerns the gene CASR and nonpapillary renal cell carcinoma.