TP53 and nonpapillary renal cell carcinoma: The KEGG pathway analysis (Supplementary Table S2) indicated that the upregulated DEGs were significantly enriched in 60 terms, such as cell adhesion molecules, focal adhesion, ECM-receptor interaction, and HIF-1, PI3K-AKT, P53 and Rap1 signaling pathway; and the downregulated DEGs were remarkably enriched in 18 terms, such as carbon metabolism, glycolysis/gluconeogenesis, and PPAR signaling pathway, which were all related to the occurrence and development of ccRCC.