EGFR and esophageal squamous cell carcinoma: In a retrospective study on 447 patients, the survival rate of patients with high EGFR expression is significantly lower than that of patients with low EGFR expression (p = 0.000), the 5-year survival rates were 18.2%, and 41.5%, respectively [19]. In addition to protein overexpression, EGFR gene amplification was observed in ESCC [16], which indicated anti-EGFR therapies might be appropriate for patients in ESCC.