IFNG and neoplasm: [70] The positive effects of siIDO were also observed when delivered by MgAl hydroxide nanoparticles [71]. When combined with Trp2, a melanoma-associated antigen, it was demonstrated that siIDO resulted in tumor growth reduction, increased CTL activity and elevated levels of serum IFN-γ [71]. The authors speculated this was due to presentation of the peptide by the DC whilst the siIDO removed immunological inhibition [71].