Additional mechanisms by which elevated angiotensin II might contribute to Alzheimer's disease are through its reported anticholinergic effects, whereas several preclinical studies have shown that ARAs such as losartan, telmisartan, valsartan, and olmesartan either prevented angiotensin II-mediated Alzheimer's disease-like pathologies in aged rodents or reduced rates of cognitive decline and the extent of pathology in various murine models of Alzheimer's disease.6 This evidence concerns the gene AGT and early-onset autosomal dominant Alzheimer disease.