The opposing findings to date highlight the importance of other studies yet to complete, which are also testing the angiotensin hypothesis of Alzheimer's disease (ie, that excess angiotensin II signalling resulting from imbalance in the brain RAS contributes to the pathogenesis of Alzheimer's disease)6 by investigating various ARAs in populations with no cognitive impairment but at risk of developing dementia (ie, HEART [NCT02471833]30 and the rrAD study [NCT02913664]) or with mild cognitive impairment (CEDAR [NCT02646982]). Here, AGT is linked to Alzheimer disease.