Findings during the COVID-19 pandemic indicating how angiotensin II type 1 receptor antagonists (ARAs) might also indirectly promote ACE2 expression, suggest that ARAs might similarly have a benefit in Alzheimer's disease by reducing classic RAS (involved in angiotensin II signalling) activity, while promoting regulatory RAS (involved in angiotensin II metabolism).8 This evidence concerns the gene ACE2 and Alzheimer disease.