APOE and Alzheimer disease: Notably, after mCRP stimulation in vivo, ApoE4 BECs showed significantly increased, but ApoE2 BECS decreased, gene expression related to four pathways linked to neurodegenerative processes (1) oxidative phosphorylation, (2) mitochondrial metabolism, (3) mTORC1 signaling and (4) AD pathology (Figure 5b,d,e).