IDH1 and central nervous system cancer: Recently, it was reported that in the presence of 1p/19q deletion and IDH1-mut, the expression of integrin beta-1 (ITGB1) was reduced compared to IDH1-mut, but a knockdown of α6β4 integrin in 1p/19q intact glioma cells (in vitro) and patient-derived glioma cells led to a decreased glioma development [75] (Fig. 2).