Additionally, DE-71 can increase exocytosis in PC12 pheochromocytoma endocrine cells (Dingemans et al. 2008) possibly by interfering with intracellular calcium dynamics (Coburn et al. 2008) and potentially increasing secretion of stored AVP depots in axonal terminals located in the posterior pituitary and, thus, releasing AVP into the bloodstream. The gene discussed is AVP; the disease is hereditary pheochromocytoma-paraganglioma.