In the face of rising Spike mutations and spread of viral variants, vascular thrombosis has been recognized as contributing to increased mortality in COVID‐19 patients,[33] and emerging cases of apparent secondary immune thrombosis after SARS‐CoV‐2 vaccination have been reported and reached public health issue.[34] Despite different vehicles, all the SARS‐CoV‐2 vaccinations share the use of Spike sequence (RNA/DNA) or protein for host immune response stimulation.[35]. Here, CHMP5 is linked to COVID-19.