Interestingly, CDK16 was highly expressed (Fig.1A–D) and preferred proximal poly(A) site (indicated by negative ΔPDUI values; Fig. 1E) in these four cancer types, indicating the potential association between upregulated gene expression and shortened 3′UTR of CDK16 in tumors, which is in line with previous observations of global 3′UTR shortening and related expression changes in multiple cancers [35]. The gene discussed is CDK16; the disease is cancer.