TLR7 and COVID-19: Thus, as human TLR7 is essential for immunity against SARS-CoV-2 and TLR7 deficiency underlies life-threatening COVID-19 pneumonia, while A-T patients without TLR7 deficiency control SARS-CoV-2 well, our patient with both autosomal recessive A-T and X-linked recessive TLR7 deficiency had critical COVID-19 because of TLR7 deficiency.