Enhanced tinnitus-related distress, as observed in patient groups with BDNF Val66 Met polymorphism (Vanneste et al. 2018a) would be compatible with BDNF bridging glucocorticoid effects on brain networks through BDNF driven phosphorylation of glucocorticoid receptor (Jeanneteau et al. 2019). This evidence concerns the gene BDNF and Tinnitus.