Mouse CXCL1 and CXCL2 (CXCL1/2) are well-established functional homologs of human CXCL8 (IL8), whose expression is also induced by NF-κB36–38 in obesity and insulin resistance39–44. The gene discussed is CXCL2; the disease is obesity due to melanocortin 4 receptor deficiency.